How is palliation provided in case of brain metastasis?

This document was last updated April 7, 2000.

Brain metastasis is suspected when a patient with a lung cancer has headaches or disturbances of brain function such as changes in thinking, speech, vision, balance and muscular activity, among others. When a brain metastasis is suspected, a computerized tomogram CT scan or MRI scan is indicated. If metastases are found, neurologic or neurosurgical consultation is in order and corticosteroids may be required to avoid complications caused by swelling of the brain. Brain metastasis is usually treated with radiation therapy.

Recent advances in this area include the ability of radiation therapists to more accurately target brain metastases using a new technique called stereotactic radio-surgery.

Stereotactic Radiosurgery (SRS)-alone and SRS+whole brain radiotherapy (WBRT) seem tp be superior to WBRT-alone in prolonging survival time, enhancing local control, and improving [QOL] for patients with single brain metastasis from lung carcinoma," the authors wrote. "Additional randomized trials are greatly needed to evaluate the value of adding whole brain radiation to SRS in the management of these patients." (Li B, et al. Int J Cancer [Radiat Oncol Invest] 2000;90:37-45.) From FAX Watch.

In some carefully selected cases, the tumor can be surgically removed by a neurosurgeon and the patient cured.


CT scan of brain demonstrating multiple brain metastases from bronchogenic carcinoma. Submitted by Ben Medley MD Scottsdale AZ.

More information on this topic is available at Brain metastases



Frederic W. Grannis Jr. M.D
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